The main aim of this course is to provide the details advanced bioreactors used in industrial scale from the design and operation point of view.

  • Course Title: Advanced Bioreactors
  • Presented for: PhD Students
  • Course No: 211411101
  • Credits/Weeks: 3/17
  • Semester: Spring
  • Group Presenting: Biotechnology



Part I) Suspended growth advanced bioreactors    

Anoxic/Aerobic bioreactors for nitrogen removal

Advanced bioreactors for phosphorus removal

Aerated lagoons and wetlands


Part II) Attached growth and combined bioreactors                                        

Biofilm kinetics and aerobic biofilm processes

Trickling filters, Rotating biological contactors

Submerged attached growth, Fluidized-Bed Bioreactors

Anaerobic Sludge Blanket Process, UASB

Bubble column and Airlift bioreactors



Ref 1- Metcalf & Eddy Inc., G. Tchobanoglous, F. L Burton, H.D. Stensel, “Wastewater Engineering: Treatment and Resource Reuse”, McGraw Hill Higher Education, 2002. (Chapters: 8-11)

Ref 2-   B.E. Rittman, P. L. McCarty, “Environmental Biotechnology: Principles and   Applications”, Prentices-Hall, 2001. (Chapters: 4, 7, 8)

Useful References:

  1. M.S. Cabral, M. Mota, J. Tramper, “Multiphase Bioreactor Design”, Taylor & Francis, 2001.
  2. L. Shuler, F. Kargi, “Bioprocess Engineering”, 2nd edition, Prentice-Hall, 2002.
  3. Villadsen, J. Nielsen, G. Liden, “Bioreaction Engineering Principles”, 3rd Edition, Springer, 2011.
  4. F. Stanbury, A. Whitaker, S.J. Mall, “Principles of Fermentation Technology”, 2nd Edition, Butterworth Heinemann, 1999.
  5. E. Bailey, D.F. Ollis, “Biochemical Engineering Fundamentals”, 2nd Edition, McGraw- Hill, 1986.
  6. L. Lehninger, D.L. Nelson, M.M. Cox, “Lehninger Principles of Biochemistry”, 6th Edition, W.H. Freeman, 2013.
  7. C. Flickinger, S.W. Drew, “Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation”, Wiley, 1999.


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Examination method

Exam 50-80%
Project 15-35%
Home works 5%

Teaching Method: Lectures