Bioreactor Design

Credits/Weeks: 3/17
Semester: Spring
Group Presenting: Biotechnology

The main aim of this course is to provide a basis for modeling and design of real bioreactors.

Aims/Scope/Objectives

*Non-ideal flow*	*Part I*
Basics of Non-ideal flow, Compartment models, Dispersion Model, Tanks-in-series model
*Sterilization*	*Part II*
Medium sterilization, Design of Batch sterilization process, Del factor, Richard’s rapid method, Scale up of batch sterilization, Design of continuous sterilization,
*Solid State Fermentation*	*Part III*
Overview, Types of SSF, Mathematical Modeling, Design of SSF processes
*Scale up/down*	*Part IV*
Fundamentals of changing scale

Textbook:

Villadsen, J. Nielsen, G. Liden, “Bioreaction Engineering Principles”, 3^rd Edition, Springer, 2011.
Van’t Riet, J. Tramper, “Basic Bioreactor Design”, Marcel Dekker, 1991.
Levenspiel, “Chemical Reaction Engineering”, 3^rd Edition, Wiley, 2006.
G. Hill, T.W. Root, “Introduction to Chemical Engineering Kinetics and Reactor Design”, 2^nd Edition, Wiley, 2014.
D.A. Mitchell, N. Krieger, M. Berovic, “Solid State Fermentation Bioreactors: Fundamentals of Design and Operation”, Springer, 2006.

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Exam 90%

Home works 10%

Teaching Method: Lectures